Mesua ferrea L. (Calophyllaceae) exerts therapeutic effects in allergic asthma by modulating cytokines production in asthmatic rats

In the present study, ethanolic extract of Mesua ferrea L. stamens was investigated for its potential to reverse some features bronchial asthma in ovalbumin-induced murine model asthma. commonly called nagakeshar (Family, Calophyllaceae) is a well-known antiallergic drug Asian folk system medicines. work, pharmacological studies are done provide scientific evidence therapeutic plants allergic Asthma induced experimental rats with allergen suspension ovalbumin and aluminium hydroxide followed by treatment dexamethasone (2.5 mg/Kg, p.o) or M. stamen (3.75 15 b.w., p.o). Biomarkers inflammatory response including cell counts, Immunoglobulin E, cytokines such as interleukin (IL)-4, -5, -1ß, tumor necrosis factor (TNF)-?, leukotriene (LT)-D-4, nitrite concentration blood well (BAL) fluid were tested. Lung functions asthmatic treated animals evaluated breathing rate tidal volume. Treatment (MFE) markedly (p < 0.001, p 0.01 0.05) diminished infiltration cells, IgE, cytokines, nitrites blood/serum fluid. Improvement lung after MFE also supports our findings. Results study suggest that can be related ability attenuate cells thereby, production proinflammatory airways.